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pentobarbital will decrease the extent or influence of guanfacine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Sturdy or average CYP3A4 inducers noticeably minimize guanfacine plasma concentrations and elimination 50 %-lifetime.Warning when discontinuing CYP3A4 inducers that are coadministered wi